QChip1 High Confidence Pathogenic Variants

Phenotype DbSNP Axiom ID Chr:Pos:Ref:Alt (GRCh38) HGVS Annotation Assertion from ClinVar Genotype Counts (Hom:Het:WT) Qatar Kuwait GME Iran NYC PR
Amyotrophic lateral sclerosis type 10 rs80356718 AX-86597715 1:11022209:A:G NM_007375.3(TARDBP):c.800A>G (p.Asn267Ser) 0:6:2701 0.0011 0.0011 0.0012 0.0013 0.0000 0.0000
Homocystinuria due to methylene tetrahydrofolate reductase deficiency rs776483190 AX-168649202 1:11802980:C:T NM_005957.4(MTHFR):c.137G>A (p.Arg46Gln) 0:1:2705 0.0002 0.0000 0.0000 0.0000 0.0000 0.0000
Ehlers-Danlos syndrome, hydroxylysine-deficient rs121913550 AX-96097180 1:11958627:C:T NM_000302.4(PLOD1):c.955C>T (p.Arg319Ter) 0:4:2703 0.0007 0.0000 0.0000 0.0000 0.0000 0.0000
Glaucoma 1, open angle, A rs74315339 AX-86638140 1:171652468:C:A NM_000261.2(MYOC):c.144G>T (p.Gln48His) 0:6:2702 0.0011 0.0000 0.0005 0.0000 0.0000 0.0000
Central centrifugal cicatricial alopecia rs142129409 AX-169127655 1:17262194:T:A NM_016233.2(PADI3):c.335T>A (p.Leu112His) 0:2:2706 0.0004 0.0000 0.0045 0.0050 0.0000 0.0000
Central centrifugal cicatricial alopecia rs139876092 AX-83022656 1:17267938:C:T NM_016233.2(PADI3):c.628C>T (p.Arg210Trp) 0:2:2702 0.0004 0.0053 0.0010 0.0000 0.0000 0.0000
Central centrifugal cicatricial alopecia rs139426141 AX-83588778 1:17270903:A:G NM_016233.2(PADI3):c.856A>G (p.Thr286Ala) 0:18:2683 0.0033 0.0021 0.0025 0.0000 0.0133 0.0196
Central centrifugal cicatricial alopecia rs144080386 AX-83286554 1:17270928:C:T NM_016233.2(PADI3):c.881C>T (p.Ala294Val) 0:7:2697 0.0013 0.0021 0.0030 0.0050 0.0022 0.0000
Central centrifugal cicatricial alopecia rs140482516 AX-83477985 1:17280704:C:T NM_016233.2(PADI3):c.1669C>T (p.Arg557Trp) 0:3:2703 0.0006 0.0032 0.0015 0.0000 0.0066 0.0098
Central centrifugal cicatricial alopecia rs34097903 AX-30261485 1:17280779:G:A NM_016233.2(PADI3):c.1744G>A (p.Ala582Thr) 0:15:2692 0.0028 0.0011 0.0045 0.0006 0.0089 0.0000
Usher syndrome, type 2A rs777465132 AX-86603454 1:215758743:G:T NM_206933.3(USH2A):c.11241C>A (p.Tyr3747Ter) 0:2:2704 0.0004 0.0000 0.0000 0.0000 0.0000 0.0000
Usher syndrome, type 2A rs746551311 AX-92024453 1:216196582:G:A NM_206933.3(USH2A):c.4222C>T (p.Gln1408Ter) 0:2:2704 0.0004 0.0000 0.0000 0.0000 0.0000 0.0000
Porphyria cutanea tarda rs121918066 AX-86633207 1:45015389:G:A NM_000374.5(UROD):c.995G>A (p.Arg332His) 0:1:2702 0.0002 0.0000 0.0000 0.0013 0.0000 0.0000
Methylmalonic acidemia with homocystinuria rs796051995 AX-168644327 1:45507491:C:T NM_015506.3(MMACHC):c.217C>T (p.Arg73Ter) 0:1:2704 0.0002 0.0000 0.0000 0.0000 0.0000 0.0000
Leber congenital amaurosis 2 rs61752871 AX-86734272 1:68444858:G:A NM_000329.3(RPE65):c.271C>T (p.Arg91Trp) 0:2:2706 0.0004 0.0000 0.0000 0.0006 0.0000 0.0000
Advanced sleep phase syndrome, familial, 3 rs139315125 AX-83301932 1:7809900:A:G NM_016831.3(PER3):c.1247A>G (p.His416Arg) 0:7:2701 0.0013 0.0021 0.0005 0.0038 0.0000 0.0000
Parkinson disease 7 rs74315352 AX-83111924 1:7984930:A:C NM_007262.5(PARK7):c.446A>C (p.Asp149Ala) 0:1:2704 0.0002 0.0000 0.0000 0.0000 0.0000 0.0000
Stargardt disease* rs1800553 AX-83425312 1:94008251:C:T NM_000350.2(ABCA4):c.[5512C>G;5882G>A] 3:106:2594 0.0207 0.0170 0.0211 0.0256 0.0089 0.0098
Stargardt disease rs61750155 AX-86636652 1:94021695:G:T NM_000350.3(ABCA4):c.4793C>A (p.Ala1598Asp) 0:3:2698 0.0006 0.0000 0.0010 0.0006 0.0000 0.0000
Leber congenital amaurosis 9 rs150726175 AX-83009255 1:9982630:G:A NM_022787.4(NMNAT1):c.769G>A (p.Glu257Lys) 0:1:2705 0.0002 0.0000 0.0015 0.0013 0.0000 0.0000